Solid Form Strategies for Increasing Oral Bioavailability
Small-molecule drug candidates are increasingly falling “beyond the rule of 5,” making oral administration more challenging. Optimizing a drug’s solid form can improve its solubility and bioavailability when further molecular modifications are prohibitive. This minireview covers solid form strategies for increasing the solubility and oral bioavailability of small-molecule drugs including: Cryo-milling Salt formation Spray drying…
