An Introduction to Fragment-Based Drug Discovery (FBDD)
In this minireview, Dr. Romyr Dominique introduces three key concepts in fragment-based drug discovery and shares his favorite articles and resources on fragment-based drug discovery. Fragment-based drug discovery has emerged as a key tool for acquiring starting points for challenging targets like KRAS. By Dr. Romyr Dominique What is FBDD, or Fragment-Based Drug Discovery? Although…
What is an IND? What is a Clinical Hold? Why Do Clinical Holds Happen?
In this article, Dr. Thuy Tran, a CMC Project Leader at Servier, gives us a quick explanation of what an IND is, what a clinical hold is, and why clinical holds happen for drug discovery scientists. What is an IND? Health authorities require drug developers to provide and justify safety and efficacy information for new…
Practical PK Calculators
This page contains Drug Hunter’s practical PK calculators useful for day-to-day drug discovery, including a PK unit converter such as for uM to ng/mL unit conversion, an animal study requirement calculator for how much material to synthesize in preparation for animal studies, and a simple human equivalent dose estimator. Who doesn’t find themselves periodically scratching…
Solid Form Strategies for Increasing Oral Bioavailability
Small-molecule drug candidates are increasingly falling “beyond the rule of 5,” making oral administration more challenging. Optimizing a drug’s solid form can improve its solubility and bioavailability when further molecular modifications are prohibitive. This minireview covers solid form strategies for increasing the solubility and oral bioavailability of small-molecule drugs including: Cryo-milling Salt formation Spray drying…
Phase I Drug Metabolism
This article explains what Phase I drug metabolism is, contains a poster summarizing common enzyme-mediated drug metabolism reactions, and provides interesting examples of phase I biotransformations and their impact on drug pharmacology. By Drake Anthony Russell, reviewed by Dr. Dian Su and Dr. Julia Shanu-Wilson. Thanks to Hypha Discovery for their support of this independently…
Drug Discovery Blogs and Influencers
Reading the thoughts of industry leaders is one of the best ways to grow as a drug discovery professional. This table contains a list of some of the best drug discovery blogs and biopharma social media influencers. They’re all clearly passionate about what they do and great free resources. More background on each appears below…
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