The Resurgence of Antibody-Drug Conjugates – FDA Approved ADCs and Linker-Payloads
Antibody-drug conjugates (ADCs) have gone through several waves of enthusiasm since being first tested in animal models in the 1960’s. The first clinical trials with ADCs were conducted in the 1980’s, and an ADC was first approved in 2000 (Mylotarg, see below). Mylotarg, however, was famously withdrawn from the market first, before being reintroduced in 2017. In…
