When interpreting compound pharmacokinetic (PK) data, it’s helpful to have reference values to compare experimental data to. A compound with a measured rat clearance value of 0.3 L/hr/kg, for example, is being removed at a slow rate relative to rat liver blood flow (3.3 L/hr/kg), indicating that the compound is not rapidly metabolized or excreted upon passage through the liver. A compound with a suprahepatic rat clearance value of 6.6 L/hr/kg, on the other hand, is apparently being removed faster than blood travels through the liver, suggesting that the either the liver is not the only organ contributing to compound removal, or that the compound is unstable in the blood. Here is a table I’ve found helpful as a “PK cheat sheet” over the years for interpreting PK data. (This was given to me by my first supervisor, Hilary Beck, but I think this might be the original data compilation: Davies, B.; Morris, T. “Physiological Parameters in Laboratory Animals and Humans.” Pharm. Res. 1993, 10, 1093-1095. doi: 10.1023/A:1018943613122) I don’t know why some companies prefer sharing data in L/hr/kg vs. mL/min/kg units, but it’s helpful for paper-reading to just memorize there are ~17 mL/min in a L/hr. Enjoy this PK cheat sheet!
Explore dhdevsite0.wpengine.com for more.