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Drug Discovery Journals

This table contains a list of some of the best drug discovery journals. This list is not exhaustive (there’s literally hundreds in our team RSS feed) but this is a subjective list of where to find the most useful drug discovery articles for one entering the field. Experts all have their own list based on their therapeutic area(s) and focus areas. This doesn’t include major general publications such as Nature, Science, PNAS, or Cell, where the focus is not on drug discovery in particular, though key drug discovery papers will appear there.

JournalAreaNotes
Medicinal Chemistry Reviewshttps://www.acsmedchem.org/?nd=armc#Small Molecule Drug DiscoveryMCR is an annual series that contains detailed drug discovery stories and reviews from leaders in the field. It contains numerous must-read articles every year.
Annual Reports in Medicinal Chemistryhttps://www.sciencedirect.com/bookseries/annual-reports-in-medicinal-chemistry#Small Molecule Drug DiscoveryARMC was the spiritual predecessor to MCR before ACS launched MCR.
Nature Reviews Drug Discoveryhttps://www.nature.com/nrd/#Drug DiscoveryNRDD contains articles of wide scope and high important on key topics in drug discovery, including for both small and large molecules, and other modalities.
J. Med. Chem.https://pubs.acs.org/journal/jmcmar#Small Molecule Drug DiscoveryJMC contains case studies of high impact small molecule drug discovery programs and important reviews.
Molecular Cancer Therapeuticshttps://mct.aacrjournals.org/#Small and Large Molecule Drug DiscoveryBecause new modalities such as biologics and cell therapies are often tested in cancer first, MCT is a great source for first disclosures of drugs with new mechanisms of action.
ACS Med. Chem. Lett.https://pubs.acs.org/journal/amclct#Small Molecule Drug DiscoveryAMCL contains timely short communications on high impact small molecule discovery programs.
Bioorg. Med. Chem. Lett.https://www.sciencedirect.com/journal/bioorganic-and-medicinal-chemistry-letters#Small Molecule Drug DiscoveryBMCL contains short communications on interesting small molecule discovery programs, often with interesting structures. BMCL Digests are also great reviews on timely topics.
Bioorg. Med. Chem.https://www.journals.elsevier.com/bioorganic-and-medicinal-chemistrySmall Molecule Drug DiscoveryBMC contains longer articles on drug discovery programs and many European and Japanese companies’ clinical candidates can be found here.
Journal of Pharmacology and Experimental Therapeuticshttps://jpet.aspetjournals.org/#PharmacologyJPET contains pharmacological details on drug compounds, and often interesting mechanisms of action are disclosed here.
Drug Metabolism and Dispositionhttps://dmd.aspetjournals.org/#ADMETDMD often contains interesting new insights into how drugs are metabolized and lead to their effects in vivo.
New England Journal of Medicinehttps://www.nejm.org/#Clinical DataNEJM is the leading publication for clinical data, and high profile trial data is often released here first.

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