Small Molecules of the Month – May 2020

Here’s May’s round-up of small molecule highlights, with comments and links to articles below. There was a lot of diversity among targets last month, although there were surprisingly few structure-based campaigns disclosed. Plenty of interesting biology and chemical structures to …

Small Molecules of the Month – Apr. 2020

April 2020 was another great month for drug discovery publications, with several interesting first disclosures of clinical candidates and a variety of uncommon chemical motifs that will pique most chemists’ interest. Here’s a visual summary of the molecules, with some …

Small Molecules of the Month March

Small Molecules of the Month – Mar. 2020

With the all the newsflow on drug re-purposing for the coronavirus, it’s easy to overlook all the interesting drug discovery articles that have been published in March. A summary of some of the most interesting compounds that appeared online this …

Approved Covalent Drug Mechanisms

It’s hard not to think about infectious diseases at the moment, but it’s a great time to review the drug discovery literature. One area of drug discovery that has deep roots in infectious disease research is targeted covalent inhibition. Targeted …

Small Molecules of the Month – Jan.-Feb. 2020

A lot of very interesting drug discovery campaigns have already been published online this year. A summary of some of the resulting small molecules that I found most interesting appears below, including several clinical candidates and many fit-for-purpose biological tool …

2019 Biotech IPOs – Biologic Drug R&D

Of the 2019 biotech IPOs on the major US exchanges, there were 24 companies focused on developing non-small molecule drugs, about the same number as those developing small molecule drugs. Here’s a list of the companies (by market cap at …