Small Molecules of the Month – Jun. 2021

June’s edition of Small Molecules of the Month features a natural product-derived RNA splicing modulator, a mTORC1-selective “bi-steric” inhibitor, numerous low-dose clinical candidates and several unusual chemical motfs (e.g. pyridine N-oxide, sulfinylamine, boronic acid).  Links to articles, PDF download, and …

Small Molecule Immunomodulators – H1 2021

By Christian Gampe While biologic drugs currently dominate in immunology by sales, small molecule immunomodulators (SMIMs) are making a comeback fueled by better understanding of intracellular signaling pathways and new hit finding technologies. SMIMs can be grouped into two categories: …

Small Molecules of the Month – May 2021

In May’s edition of Small Molecules of the Month, we have several fascinating molecules including a mutant PI3Kα degrader in Ph. III (GDC-0077, inavolisib), a wild-type CFTR potentiator for COPD, and a Ph. III chemotherapeutic derived from an aerospace compound. …