The September edition of Small Molecules of the Month, features a number of fascinating molecules and mechanisms, including a beta-lactamase inhibitor optimized to have single agent antibiotic activity, a biased agonist of S1P1 that minimizes receptor internalization in favor of GCPR agonism, an oral AR degrader similar to ARV-110 and a molecule that unfortunately demonstrates QTc prolongation in vivo without a significant in vitro signal. Special thanks to reviewer Mike Koehler for commentary on the cover molecule, ETX0462, this month.
September 2021
- ETX0462
- milvexian
- GSK3685032
- JNJ-64619178
- vimseltinib
- ARD-2585
- AZD5305
- SAR247799
- IM156
- BMS-986158
- JNJ-67569762
- FRM-024
- LYC-55716
- S-600918