molecules of the month

September 2021

The September edition of Small Molecules of the Month, features a number of fascinating molecules and mechanisms, including a beta-lactamase inhibitor optimized to have single agent antibiotic activity, a biased agonist of S1P1 that minimizes receptor internalization in favor of GCPR agonism, an oral AR degrader similar to ARV-110 and a molecule that unfortunately demonstrates QTc prolongation in vivo without a significant in vitro signal.

Special thanks to reviewer Mike Koehler for commentary on the cover molecule, ETX0462, this month.

A slide deck with more details about each molecule is available.

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past molecules of the month

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molecules of the year nominees

Previous selections for Drug Hunter’s Molecule of the Year below.

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molecules of the year

Previous selections for Drug Hunter’s Molecule of the Year below.

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