Many more modalities, mechanisms, screening strategies, and interesting chemical motifs appeared from the drug discovery community in July. This time we have a compound from a DNA-encoded library screen, some compounds derived from phenotypic screens, and a starting point identified from a high-throughput mass screen. We also have the first cryo-EM structure featured this year from the GNF team at Novartis, and a co-crystal structure with a normally membrane-bound protein thanks to Sosei Heptares. Links to the articles and more discussion on specific molecules below.
July 2020
- A-1331852
- dotinurad (FYU-981)
- X-165
- "compound 38a"
- HTL22562
- "compound 23"
- MGS0274
- LXE408
- "compound 2"
- AB680
- "compound 18"
- ETX0282
- "compound 6g"
- EC2629