X-165 is an autotaxin inhibitor clinical candidate for idiopathic pulmonary fibrosis discovered using a 3-cycle DEL screen of 225M compounds derived from amide couplings. An unusual spirocyclic amine building block was responsible for most of their non-phosphonate-containing high-enrichment hits. The initially resynthesized hits had [...]
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Sep. 18, 2021
X-165: A Potent, Bioavailable Autotaxin Inhibitor
X-165
potent, bioavailable autotaxin inhibitor orally active in fibrosis mod., Ph. I IND cleared from 225M cmpd DNA-encoded library + opt. J. Med. Chem., Jul. 23, 2020 X-Chem, Waltham, MA
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