Tucatinib is the third approved HER2 kinase inhibitor (after lapatinib and neratinib), but differentiates itself due to its selectivity against the closely related EGFR, which is hypothesized to be a source of undesired side effects with prior inhibitors. Impressively, it’s also demonstrated activity in HER2+ breast cancers with brain [...]
< 1 minute read
Sep. 17, 2021
Tucatinib: EGFR-Sparing HER2 Kinase Inhibitor
tucatinib
EGFR-sparing HER2 kinase inhibitor approved in met. HER2+ BC incl. w/ brain met. from optimization of known TKIs Mol. Cancer Ther., Apr. 1, 2020 Array / Cascadian Tx / Seattle Genetics