sAC as a target for male contraception. Soluble adenylyl cyclase (sAC) is one of several ACs that catalyze the cyclization of ATP to form cyclic adenosine monophosphate (cAMP). cAMP is the second messenger in several signaling pathways including that which activates sperm to be capable of fertilizing eggs (“ capacitation ”). The target is [...]
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Dec. 28, 2022
TDI-11861: sAC As a Male Contraception Target
TDI-11861
oral sAC inhibitor intended for male contraception opt. from TDI-10229 + SBDD J. Med. Chem., 08 November 2022 Tri-I TDI/Weill Cornell Medicine, New York, NY