Chemical structure of TAK-906 Altos Therapeutics/Takeda D2/D3 receptor antagonist

peripherally-restricted D2/D3 antagonist

oral agent for gastroparesis in Ph. II

up to 100 mg PO BID

JPET, Clinical Pharmacology

Altos Therapeutics / Takeda, Cambridge

The Altos Therapeutics/Takeda D2/D3 receptor antagonist, TAK-906, is a peripherally-restricted, non-BBB penetrant molecule, targeting the stomach and vomiting center in the area postrema to treat gastroparesis. Gastroparesis is a chronic condition…


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