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Dec. 16, 2021

TAK-653: an AMPA-R Potentiator

TAK-653

potent AMPA-R potentiator w/ min. agonism 6 mg PO QD in Ph. II (withdrawn, biz decision) from biochemical screen + opt. Scientific Reports Takeda Pharmaceutical, Fujisawa, JP

drughunter.com
Drug Hunter Team
Reviewer:  

The Takeda AMPA-R potentiator, TAK-653 , is a glutamate-dependent potentiator that exhibits minimal agonism. AMPA-R agonism is associated with seizure risk and bell-shaped dose-response effects. As reviewer Jake Schwarz notes, companies including Cortex Pharmaceuticals (now RespireRx) and Lilly have been trying to develop AMPA modulators for [...]

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