SR-717 is STING agonist with a surprisingly similar mechanism to MSA-2, published contemporaneously with MSA-2. The identification of a second carboxylic acid-type molecule with both 2:1 binding stoichiometry and apparent tumor selectivity support both papers’ MoA hypotheses.
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Sep. 18, 2021
SR-717: Non-Nucleoside STING Agonist
SR-717
non-nucleoside STING agonist single agent systemic activity in I/O model from 100k cmpd cellular pheno. screen + opt. Science, Aug. 21, 2020 TSRI / Calibr, La Jolla, CA
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