5 minute read
Sep. 28, 2022

SPH3127: an Oral Direct Renin Inhibitor (DRI) for Hypertension

SPH3127

oral Renin Inhibitor Ph. III candidate in essential hypertension SBDD and PK profile opt J. Med. Chem. Mitsubishi Tanabe, Yokohama, JPShanghai Pharmaceuticals, Shanghai, CN

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Drug Hunter Team

SPH3127 (Mitsubishi Tanabe and Shanghai Pharmaceuticals) is an oral direct renin inhibitor (DRI) being developed for hypertension. The renin-angiotensin-aldosterone system is responsible for regulating blood pressure. Existing drugs treat hypertension by targeting angiotensin-converting enzyme (ACE) and the angiotensin II receptor [...]

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