mut. BRAF sel. heterobifunctional degrader

efficacy in xenograft at 50 mg/kg IP BID

VHL-based degrader from vemurafenib

Nat. Comm., Feb. 10, 2021

Yale University, New Haven, CT

SJF-0628

13. The Yale BRAF-targeting PROTAC SJF-0628 is a VHL-based heterobifunctional degrader with in vivo activity in a xenograft model (50 mg/kg BID IP). Though mutant BRAF is a well-validated…


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