Structure of SCO-267, a full agonist of the GPCR GPR40

oral full agonist of GPR40 GCPR

oral efficacy in obesity model, entered Ph. I

from optimization of prior molecule

J. Med. Chem., Sep. 24, 2020

Takeda / SCOHIA Pharma, Fujisawa, JP

SCO-267 is a full agonist of the GPCR GPR40, whose activation stimulates secretions of insulin and incretin. Since no crystal structures were available, the authors used conformational modeling to rationally…


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