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Nov. 26, 2021

SAR247799: A Biased Agonist of the S1P1 Sphingosine Receptor

SAR247799

G-protein biased GPCR agonist oral 10 mg QD, phase I, cardiovascular from HTS and opt. bioRxiv Sanofi

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Drug Hunter Team

The Sanofi S1P1 agonist, SAR247799 , is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G-protein signaling over the β-arrestin and internalization pathways. Commercial S1P1 modulators such as fingolimod and ozanimod exert their immunosuppressive effects in multiple sclerosis and other diseases primarily by [...]

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