The Shionogi P2X3 ligand-gated ion channel antagonist, sivopixant ( S-600918 ), is an oral Ph. II candidate for refractory chronic cough, which recently completed a its Ph. IIb study, overcoming the projected high dose requirement of a prior preclinical candidate. The molecule has a very polar core structure with both a dioxotriazine and [...]
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Nov. 26, 2021
Sivopixant: A P2X3 ligand-gated Ion Channel Antagonist
S-600918
purinergic receptor (ion channel) antagonist up to 300 mg PO QD, phase IIb, chronic cough from opt. of prior P2X3 antagonist Bioorganic and Medicinal Chemistry Letters Shionogi
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