mTORC1-selective bi-steric mTOR inhibitor

QW IP activity in xeno., 5552 in Ph. I for cancer

from linking of ÒrapalogÓ + mTOR inh. + opt

Nature Chemical Biology

Revolution Medicines, Redwood City, US


3. The Revolution Medicines selective mTORC1 complex inhibitor, RMC-4529, is a Òbi-stericÓ inhibitor that has a rapamycin-derived, FKBP12-recruiting allosteric mTOR inhibitor covalently linked to an active-site (orthosteric) inhibitor of…

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