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molecules of the month

Remogliflozin etabonate

SGLT1-sparing oral SGLT2 inhibitor prodrug

launched in India for diabetes, 100 mg BID

from mouse urine drug metabolite and opt.

Bioorg. Med. Chem., Jan. 22, 2021

Kissei Pharma / Toho University, JP

Remogliflozin-etabonate
1 min read

The Kissei SGLT2 inhibitor prodrug, remogliflozin etabonate, is an SGLT1-sparing oral drug launched in 2019 in India for the treatment of type 2 diabetes.  Interestingly, the lead for this drug was a metabolite identified from mouse urine after treatment with a Wyeth-Ayerst antihyperglycemic agent of previously unknown mechanism. 


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