>300-fold family-selective PARP14 inh. tool

90x IC50 coverage at 500 mpk BID PO in vivo

from PARP-preferring directed library + SBDD

Cell Chem. Bio., Mar. 10, 2021

Ribon Therapeutics, Cambridge, MA

The Ribon Therapeutics PARP14 inhibitor (RBN-012759) is a tool compound with >300x selectivity over all PARP family members. While PARP1/2 are well-known to drug hunters as synthetic lethal targets…

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