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molecules of the year

“PROTAC 6”

IAP-based selective RIPK2 degrader

prolonged PD w/ 0.15 mpk SC Q3D dosing

E3 binder switch and property-based opt.

Commun. Biol., Mar. 20, 2020

GlaxoSmithKline, Stevenage, UK / PMCC

“PROTAC 6”
1 min read

“PROTAC 6” (GlaxoSmithKline (GSK) IAP-based selective RIPK2 degrader with prolonged in vivo PD)


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