Pevonedistat Chemical Structure, intravenous NEDD8-activating enzyme inhibitor - Takeda, Lexington, MA

intravenous NEDD8-activating enzyme inhibitor

Ph. III candidate for oncology

from HTS and optimization

Drug Metab. Dispos.

Takeda, Lexington, MA

Context. Pevonedistat (Takeda) is a first-in-class intravenous or subcutaneous NEDD8-activating enzyme (NAE) inhibitor being developed for leukemia and advanced solid tumors. NAE is a pivotal regulator of the NEDD8…


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