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Sep. 18, 2021

ONO-8430506: A potent autotaxin phosphodiesterase inhibitor

ONO-8430506

potent oral autotaxin phosphodiesterase inh. orally efficacious in xenograft from HTS and ligand-based design ACS Med. Chem. Lett., May 19, 2020 Ono Pharmaceutical, Osaka, JP

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Drug Hunter Team

ONO-8430506 is a potent autotaxin phosphodiesterase inhibitor with significant oral exposure and low clearance in higher species. Autotaxin contributes to lysophosphatidic acid (LPA) production has been explored as a target in various diseases involving LPA signalling including IPF (GLPG1690, Ph. III), hyperplasia, and cancer (this paper) [...]

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