NVP-CLR457 Chemical Structure, oral pan-class IA PI3K inhibitor - Novartis (NIBR), Basel, CH

oral pan-class IA PI3K inhibitor

Ph. I in advanced solid tumors

opt. from previous clinical candidat

J. Med. Chem

Novartis (NIBR), Basel, CH

Context. NVP-CLR457 (Novartis Institutes for BioMedical Research) is an oral, non-CNS-penetrating pan-class IA phosphoinositide 3-kinase (PI3K) inhibitor. Due to the key involvement of PI3K in the famed PI3K-Akt−mTOR pathway,…


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