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Sep. 18, 2021

NLG802: An Oral Prodrug of IDO1 Inhibitor

NLG802

oral prodrug of IDO1 inhibitor completed Ph. I in solid tumors from derivatization of indoximod Eur. J. Med. Chem., May 1, 2020 NewLink Genetics, Ames, IA

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Drug Hunter Team

NLG802 is a prodrug of the IDO1 inhibitor indoximod with significantly enhanced oral exposure. Both the acid and amine functionalities of indoximod are protected as an ethyl ester and leucine amide, respectively. Prodrugs are generally difficult to develop so it’s interesting that two biotransformations are employed. The molecule is first [...]

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