Indoleamine 2,3-dioxygenase 1 (IDO1) is an extrahepatic tryptophan-metabolizing enzyme which is believed to contribute to the evasion of the immune system by tumors , making it an attractive target for cancer immunotherapy, especially in combination with immune [...]
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May 29, 2023
Navoximod: An Early Heme-Binding Inhibitor of the Once Red-Hot Immunotherapy Target, IDO1
navoximod
oral IDO1 inhibitor Ph. I completed (50-800 mg) for cancer from phenylimidazole + SBDD JPET, April 14, 2023 NewLink Genetics / Genentech