MSA-2 is an orally available agonist of the STING protein, which potently induces inflammation. Clinically evaluated cyclic dinucleotide-based STING agonists have typically been dosed intratumorally to promote anti-tumor inflammation but avoid systemic inflammation. The compound binds in a 2:1 stoichiometry with STING, and forcibly dimerized [...]
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Sep. 18, 2021
MSA-2: An Oral Non-Nucleoside STING Agonist
MSA-2
oral non-nucleoside STING agonist single agent systemic activity in I/O model from 2.4M cmpd cell-based phenotypic screen Science, Aug. 21, 2020 Merck & Co., Kenilworth, NJ