oral brain-penetrant SOS1:KRASG12C PPI inhibitor

efficacy in MIA PaCa-2 tumor mouse xenograft model

from literature starting point and opt

J. Med. Chem.

Mirati Therapeutics, San Diego, CA

MRTX0902 Chemical Structure oral brain-penetrant SOS1:KRASG12C PPI inhibitor - Mirati Therapeutics, San Diego, CA

Context. MRTX0902 (Mirati Therapeutics) is an oral brain penetrating SOS1:KRAS protein-protein interaction inhibitor. Since the first report of the druggability of the KRASG12C mutant, KRAS has been a hotly…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: