MRTX0902 Chemical Structure oral brain-penetrant SOS1:KRASG12C PPI inhibitor - Mirati Therapeutics, San Diego, CA

oral brain-penetrant SOS1:KRASG12C PPI inhibitor

efficacy in MIA PaCa-2 tumor mouse xenograft model

from literature starting point and opt

J. Med. Chem.

Mirati Therapeutics, San Diego, CA

Context. MRTX0902 (Mirati Therapeutics) is an oral brain penetrating SOS1:KRAS protein-protein interaction inhibitor. Since the first report of the druggability of the KRASG12C mutant, KRAS has been a hotly…


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