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Sep. 18, 2021

MK-5204: An Orally Active Beta-1,3-Glucan Synthesis Inhibitor

MK-5204

orally active beta-1,3-glucan synthesis inhibitor eff. in fungal infect. model, discont. for alt. from semisynthetic mod. of enfumafungin Bioorg. Med. Chem. Lett., Jun. 19, 2020 Merck & Co., Kenilworth, NJ / Scynexis

drughunter.com
Drug Hunter Team

MK-5204 is a broad spectrum Candida antifungal agent derived from the natural product, enfumafungin. I was impressed that the molecule not only demonstrates oral efficacy but also has good oral PK in higher species (dog, cyno), given that the molecule is a large zwitterion with several very polar groups, including a primary amide, primary [...]

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