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Nov. 26, 2021

Milvexian: An Oral Factor XIa Inhibitor,

milvexian

selective factor Xia serine protease inhib. oral, phase II, cardiovascular from opt. of previous macrocyclic FXIa inh. Journal of Medicinal Chemistry Bristol Myers Squibb

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Drug Hunter Team

The BMS factor XIa inhibitor, milvexian (BMS-986177), is an oral antithrombotic with a Ki of 0.11 nM. A member of this macrocyclic series was previously highlighted as one of 2020’s Molecules of the Year . Poor pharmaceutic properties from previous preclinical molecules such as solubility were addressed resulting in this candidate. Milvexian [...]

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