The Lycera ROR gamma agonist, cintirorgon ( LYC-55716 ), is a first-in-class phase 1b clinical candidate for cancer immunotherapy (in combination with pembrolizumab in NSCLC). ROR gamma antagonists have been extensively pursued and studied for autoimmune conditions, but ROR gamma agonists have also been recently pursued for “pro-inflammatory” [...]
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Nov. 26, 2021
LYC-55716: An Oral RORγ Nuclear Receptor Agonist
LYC-55716
oral RORγ nuclear receptor agonist 450 mg BID, phase I/II, cancer from change in MoA of RORγ antagonist + opt. Journal of Medicinal Chemistry Lycera