fbpx

molecules of the year

Kura Oncology menin-MLL1 inhibitor

oral, QD menin-MLL1 inhibitor

Ph. I/II for leukemia

from HTS and SBDD

ziftomenib (KO-539)

Kura Oncology, San Diego, CA / UMich (Grembecka Lab)

ziftomenib
3 mins read

Ziftomenib (KO-539) is an oral menin-MLL1 protein-protein interaction inhibitor being developed for acute myeloid leukemia (AML) by Kura Oncology. This Sep. ’22 Molecule of the Month inhibits the protein–protein interaction between menin and mixed lineage leukemia (MLL) fusion proteins, an interaction that drives many leukemias. Early data from an ongoing Ph. I/II clinical trials for acute leukemias are very promising, including a response in 6/8 patients and two complete responses in heavily pre-treated patients. A partial clinical hold that was placed on the trial in November 2021 due to a patient death was subsequently lifted, which was likely associated with differentiation syndrome, a known tissue-damage adverse event related to agents that cause the differentiation of leukemic blasts. The differentiation syndrome…


request a trial

Drug Hunter is commited to helping industry innovators make informed decisions. Premium members have access to our library of the latest stories in science, written by scientists.

Request a trial to access insights powering the pros in our industry.


already a member? log in: