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Feb. 9, 2022

KB-0742: an Ultraselective Inhibitor of Cyclin-Dependent Kinase CDK9

Kronos CDK9 Inhibitor

selective CDK9 inhibitor oral Ph. I candidate for MYC-amp tumors from microarray binding assay with lysate KB-0742 Kronos Bio, Cambridge, MA

drughunter.com
Drug Hunter Team

The Kronos CDK9 inhibitor, KB-0742, is an ultraselective inhibitor of cyclin-dependent kinase CDK9. The CDK family of kinases have been pursued as cancer drug targets for decades, but family selectivity within the highly conserved kinase family has made it difficult to identify highly selective molecules, resulting in less than ideal [...]

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