topical Janus kinase (JAK) family inhibitor
approved for atopic dermatitis in JP
from scaffold hop from known JAK inhibitor
J. Med. Chem., Jun. 8, 2020
Japan Tobacco, Osaka, JP
JTE-052 (delgocitinib)
1 min read
JTE-052 (delgocitinib) is a pan-JAK kinase inhibitor approved as a topical ointment for treatment of atopic dermatitis in Japan. The compound has an interesting azetidine-containing diazaspirocycle core and a relatively high sp3-fraction for a kinase inhibitor.
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