Structure of CGRP receptor agonist HTL22562

potent, non-oral CGRP antagonist

clean profile in 10-day rodent tox.

from SBDD of prior ligand

J. Med. Chem., Jul. 23, 2020

Sosei Heptares, Cambridge, UK

HTL22562 is a CGRP antagonist intended to treat acute migraines. Some prior oral CGRP antagonists failed in clinical trials due to liver tox. signals, so this program targeted a non-oral…


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