drug hunter molecules of the year H3B-8800 splicing modulator structure

oral splicing modulator (SF3b complex)

7-20 mg 21d+/7d-, Ph. I for myeloid neoplasias

from opt. of pladienolide B natural product

H3B-8800

H3 Biomedicine, Cambridge, MA

The H3 Biomedicine RNA splicing modulator, H3B-8800, targets the spliceosome SF3b complex containing either wild-type (WT) or mutant SF3B1. Splicesome inhibition can induce synthetic lethality since cancer cells bearing spliceosome mutations are…


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