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Sep. 18, 2021

GS-9688: A Pre-Systemic Oral Toll-Like Receptor 8 Agonist

GS-9688 (selgantolimod)

pre-systemic oral toll-like receptor 8 agonist in multiple Ph. II studies for chron. hep. B from optimization of lit. dual TLR7/8 agonists J. Med. Chem., Jun. 3, 2020 Gilead Sciences, Foster City, CA

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Drug Hunter Team

GS-9688 (selgantolimod) is a potent and selective TLR8 agonist sparing related receptor TLR7, and is intended to induce better immune responses in chronic hepatitis B. Since systemic activation of TLR8 was undesirable, selgantolimod was designed to have high first-pass hepatic clearance to induce effective antiviral immunity in the liver but [...]

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