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Sep. 18, 2021

GS-6207: a p24 Glue

GS-6207

long-acting HIV capsid PPI-based inhibitor in Ph. II/III for resistant HIV (SC once/6 mo.) from HTS for binders, SBDD + opt. for funct. Nature, Aug. 27, 2020 issue Gilead Sciences, Foster City, CA

drughunter.com
Drug Hunter Team

GS-6207 is an HIV-1 inhibitor that acts on the capsid protein monomer (p24), which normally self-assembles in the HIV virion to form the capsid core that is essential for virus infectivity. GS-6207 targets a protein-protein interaction between the small (24 kDa) p24 monomers, binding in a glue-like fashion to two separate monomers, and is [...]

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