long-acting HIV capsid PPI-based inhibitor

in Ph. II/III for resistant HIV (SC once/6 mo.)

from HTS for binders, SBDD + opt. for funct.

Nature, Aug. 27, 2020 issue

Gilead Sciences, Foster City, CA

GS-6207 is an HIV-1 inhibitor that acts on the capsid protein monomer (p24), which normally self-assembles in the HIV virion to form the capsid core that is essential for…

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