GLPG1205 is a potent, selective, and orally bioavailable negative allosteric modulator of the GPCR GPR84, a receptor associated with inflammation. Despite possessing both a dioxane ring and an relatively unhindered alkyne, the molecule has low clearance and is highly bioavailable in preclinical species (>100% F). The molecule was taken into a [...]
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Sep. 18, 2021
GLPG1205: A GPR84 GPCR Negative Allosteric Modulator
GLPG1205
GPR84 GPCR negative allosteric modulator oral Ph. II candidate for IPF from 200k cmpd biochem. HTS and opt. J. Med. Chem. Sep. 29, 2020 Galapagos, Romainville, FR / Mechelen, BE
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