fbpx

molecules of the month

GLPG1205

GPR84 GPCR negative allosteric modulator

oral Ph. II candidate for IPF

from 200k cmpd biochem. HTS and opt.

J. Med. Chem. Sep. 29, 2020

Galapagos, Romainville, FR / Mechelen, BE

Structure of GLPG1205
1 min read

GLPG1205 is a potent, selective, and orally bioavailable negative allosteric modulator of the GPCR GPR84, a receptor associated with inflammation. Despite possessing both a dioxane ring and an relatively unhindered alkyne, the molecule has low clearance and is highly bioavailable in preclinical species (>100% F). The molecule was taken into a Ph. IIa trial initially for IBD, but failed to meet its primary efficacy endpoint. Currently, it is being evaluated in a Ph. II study in idiopathic pulmonary fibrosis (IPF).


request a trial

Drug Hunter is commited to helping industry innovators make informed decisions. Premium members have access to our library of the latest stories in science, written by scientists.

Request a trial to access insights powering the pros in our industry.


already a member? log in: