GPR84 GPCR negative allosteric modulator

oral Ph. II candidate for IPF

from 200k cmpd biochem. HTS and opt.

J. Med. Chem. Sep. 29, 2020

Galapagos, Romainville, FR / Mechelen, BE

Structure of GLPG1205

GLPG1205 is a potent, selective, and orally bioavailable negative allosteric modulator of the GPCR GPR84, a receptor associated with inflammation. Despite possessing both a dioxane ring and an relatively unhindered…

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