molecules of the month

Context. GCC5694A (GC Pharma (Green Cross)) is an oral SGLT2 inhibitor. SGLT2 inhibitors help glycemic control in diabetes by preventing reabsorption of glucose in the kidney. Dapagliflozin was the first SGLT2 inhibitor approved in the EU (2012), and canagliflozin was the first to be approved in the US (2013). We recently highlighted remogliflozin, an SGLT1-sparing drug launched in India in 2019 with a unique origin, and a Janssen dual SGLT1/2 inhibitor based on the natural product phlorizin. There are now eight gliflozins approved for clinical use worldwide. GCC5694A is reported to be in clinical trials in South Korea, though it is not in GC Pharma’s pipeline.Though it is not clear from the data presented how GCC5694A differentiates from previous SGLT2…