An old molecule and an old target come together. Squalamine was originally discovered in 1993 as an antimicrobial from the liver of the dogfish shark. It’s had a long and interesting history, investigated by Magainin/Genaera as a Ph. II antiangiogenic drug candidate for cancer and as a Ph. III opthalmic candidate for macular degeneration. One [...]
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Dec. 28, 2022
Squalamine: a Potential Parkinson’s Treatment
ENT-01
oral ⍺-synuclein aggregation inhibitor completed Ph. IIb for PD + constipation natural product Sci. Adv., 16 November 2022 Enterin Inc., Philadelphia, PA