EC2629 is a folate receptor (FR)-targeted small molecule drug conjugate with a folate receptor-targeting moiety, a pyrrolobenzodiazepine (PBD) DNA-crosslinking warhead, and a linker. Similar to antibody-drug conjugates, this small molecule conjugate is intended to maintain the activity of the potent PBD warhead while minimizing systemic [...]
< 1 minute read
Sep. 18, 2021
EC2629: A Folate Receptor Targeted DNA Crosslinking Agent Conjugate
EC2629
FR-targeted DNA crosslinking agent conjugate activity in xenograft w/ once weekly dosing from conjugation of FR-ligand and PBD dimer Sci. Rep., Jul. 29, 2020 Endocyte, West Lafayette, IN / Novartis
Loading...
