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oral G2019S-LRRK2 mut.-selective kinase inh.
>70x sel. for ParkinsonÕs mut. over WT, non-BP
from 50k cmpd HTS + homology-based opt.
J. Med. Chem., Nov. 16, 2020
ESCAPE Bio, South San Francisco, CA
EB-42486 (ESCAPE Bio oral G2019S-LRRK2 mutant-selective kinase inhibitor)
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