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molecules of the month

E7766 (STING)

intratumoral STING receptor agonist

in Ph. I for adv. solid tumors as single agent

from macrocyclization of cyclic dinucleotide

ChemMedChem., Jan. 31, 2021

Eisai Inc., Cambridge, MA

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Chemical structure of molecule E7766 sting agonist

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3. The Eisai STING agonist E7766 leads to tumor eradication in 9/10 treated animals in a syngeneic model when injected intratumorally, and is currently in a Ph. I study for advanced solid tumors. The molecule has an interesting macrocyclic structure, and behaves as a cyclic dinucleotide mimic with potent activity on all four human STING variants.

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E7766 (STING)

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