molecules of the month

E7766 (STING)

intratumoral STING receptor agonist

in Ph. I for adv. solid tumors as single agent

from macrocyclization of cyclic dinucleotide

ChemMedChem., Jan. 31, 2021

Eisai Inc., Cambridge, MA

Chemical structure of molecule E7766 sting agonist
1 min read

3. The Eisai STING agonist E7766 leads to tumor eradication in 9/10 treated animals in a syngeneic model when injected intratumorally, and is currently in a Ph. I study for advanced solid tumors. The molecule has an interesting macrocyclic structure, and behaves as a cyclic dinucleotide mimic with potent activity on all four human STING variants.

request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.

already a member? log in: